The Fact About rheumatoid arthritis mayo clinic That No One Is Suggesting

A growing number of people across the world are suffering because their immune systems are unable to more distinguish between healthy cells and invading micro-organisms. Instead of protecting themselves from disease the organs and tissues are attacked by these same defenses.




This issue is being addressed by major international research initiatives. One such initiative is London's Francis Crick Institute. Two world experts, James Lee (from the USA) as well as Carola Vinuesa (from Italy) have created separate research groups in order to identify the precise causes.


Lee stated that cases of autoimmune disease have been on the rise since the past 40 years, in the west. However, some of these cases are now being seen in countries that have never experienced such diseases.


For example, the Middle East and East Asia are the areas with the highest percentage of cases of inflammatory intestinal disease. They'd never seen the disease.


Autoimmune diseases be a variety of conditions, from type 1 diabetes to Sclerosis chronic fatigue syndrome, Rheumatoid Arthritis. In each of these cases, the immune system gets its wires crossed, and it turns towards healthy tissue, not infective agents.


At least 4,000,000 people suffering from autoimmune disorders in the UK and some suffer from multiple. In the world, it's estimated that cases of autoimmune diseases are rising between 3% and 9% a year. Researchers believe that environmental triggers are the primary reason for this increase.


Lee, who was previously located at Cambridge University, stated that genetics have not changed in recent years. Something is taking place outside that is increasing our risk of developing autoimmune disorders.


Vinuesa was the person who was the one who believed in this concept. Vinuesa was previously at the Australian National University. She discussed the shifts in the diets of people when more nations adopted west-style diets, and people consumed more fast food.


Vinuesa said that some vital elements in fast food diets are missing, including fibre. There is evidence that changing the microbiome of a person (the collection of microorganisms and microbes we are able to digest) could lead to the loss of specific bodily functions.


The changes in our microbiomes then trigger immune-mediated diseases, of which more than 100 types are now being identified.


Both researchers said that certain people are more prone to developing these illnesses. They include celiac and lupus, which can trigger inflammation and swelling and result in damage to various organs including the heart.


Vinuesa stated, "If there is no genetic susceptibility to an immune-mediated disease is not likely to be a problem, regardless of the amount of Big Macs we eat." We can't do about the rapid expansion of fast food chains across the world. Instead, we're trying to understand how autoimmune diseases occur and what genetic pathways cause certain individuals to be more vulnerable than others. That's the level that we are aiming to tackle this issue."


Scientists now have the ability to identify tiny differences in DNA among large numbers of people. This is possible because of the advancement of technology. It is now possible to discern common genetic patterns that are common to individuals suffering from an autoimmune condition.


Lee explained that we didn't have the technology to sequence DNA until recent. But, today we do have the incredible capability to sequence DNA on huge scales. This has made a huge difference to our daily lives. We only knew about half a dozen different variants of DNA that could cause inflammatory bowel diseases when I started my study. Today, we have more than 250.


Lee and Vinuesa have been involved in this studies since the beginning of. Their research aims to understand the different types of diseases which doctors are currently studying and to discover the genetic mechanisms that lead to them. If you take a look at a variety of immune-mediated diseases, such as the lupus disease - it's been discovered recently that there are numerous different variants of these diseases, which Read More could be caused by various genetic pathways, Vinuesa said. If you're trying find the most effective treatment for your condition it can become an issue.


There are numerous innovative therapies that are being developed, but we don’t know which patients we should give them. We don't know what type of disease the patient has. And that is now the main goal of the Click here research into autoimmune diseases. We must learn to categorize and stratify patients so that we can provide them with the appropriate therapy.


Lee stated that the growing prevalence of autoimmune diseases across the world meant that new treatment and drugs were urgently required. It is not possible to cure autoimmune diseases. This happens when young people are trying to finish their education or get their first job and start families.


It means that more patients are scheduled for surgery or be required to receive regular injections throughout the course of their lives. This could be very stressful for patients and an enormous strain on healthcare services. So, it is essential to find effective and new methods of treatment.


Rheumatoid arthritis is an immuno-mediated disease. However, we aren't sure what triggers it.


The immune system naturally produces antibodies to combat bacteria and viruses.


Rheumatoid arthritis refers to a condition in which your immune system sends antibodies to your joints. They attack the tissues around the joint.


This causes the thin synovium layer of cells that surround your joints to become swollen. The synovium also releases chemicals that could cause injury nearby.


bones

Cartilage, the connective tissue between bones.

Tendons connect bone to muscles

Ligaments are the connective tissue between cartilage and bone.

Rheumatoid arthritis can be treated but it is not managed. The chemicals can cause the joint to become unbalanced and distorted. Then, eventually, it will destroy the joint completely.


Though there are many theories that explain how the immune system attacks the joint, none has been proven.

Possible risk factors

There are a variety of factors that can increase the risk of developing rheumatoid, such as:


Your genes are a factor - there's evidence to suggest that rheumatoid arthritis may be passed down through families, but the risk of inheriting it is thought to be very low because genes are thought to play a minor role in the condition

Hormones are responsible for causing arthritis. Rheumatoid arthritis is now more prevalent than ever among women, perhaps due to the hormonal effects of oestrogen. However, this link it has not been proved.

Smoking cigarettes - Smoking increases the risk of developing rheumatoid arthritis.