5 Simple Techniques For arthritis rheumatoid arthritis

In the world, more and more and more people suffer from the inability of their immune systems to differentiate between healthy cells or invaders microscopic organisms. The defenses against diseases that were once protecting themselves are now attacking their tissue and organs.




Major international research efforts are in progress to reverse this trend. A London-based initiative called the Francis Crick Institute, has two world experts, James Lee & Carola Vinuesa established separate research teams to find the causes behind an autoimmune disorder.


Lee disclosed to the Observer the extent to which auto-immune cases has grown over the last 40 years, particularly in Western countries. However, some cases are now being observed in countries that have never experienced such diseases.


The Middle East and East Asia are experiencing the greatest growth in cases of inflammatory bowel disease. They had never seen the disease before.


Autoimmune diseases range from type 1 diabetes to rheumatoid arthritis inflammatory bowel disease and multiple sclerosis. In all instances the immune system is activated and turns on healthy tissue.


Around 4 million people in the UK have been affected by these diseases. Other people may have more than one. It is believed that autoimmune disorders are increasing by between 3to 9 percent every year around the world. Many scientists believe environmental factors are a major reason for this increase.


Lee who was once based at Cambridge University, stated that our genetic makeup has not changed over the past few decades. There must be something taking place outside that is increasing the risk of developing autoimmune disease.


This idea was backed by Vinuesa who was based at the Australian National University. She mentioned that there were changes in the diet as more people ate western-style meals, and increasing consumption of fast food.


Vinuesa says that many fast-food products lack essential ingredients such as fiber. This could alter one's microbiome that is the accumulation of of microorganisms present in our bodies which play an important part in regulating various bodily functions.


The microbiome's changes can then trigger autoimmune diseases. Over 100 kinds of autoimmune diseases have been identified.


The two scientists also stressed that everyone is susceptible to these diseases including celiac Lupus, and various other illnesses like celiac that cause swelling and inflammation and may cause severe harm to different organs.


Vinuesa claims that anyone who does not have a particular genetic susceptibility will not get an autoimmune condition, regardless of the quantity of Big Macs they eat. There is nothing we can do about the rapid expansion of fast food chains across the globe. Instead, we are focusing in understanding the genetic factors that underlie autoimmune disorders and why some individuals are susceptible while others are not. This is the stage where we plan to tackle this problem."


This task is possible thanks to the development of techniques that allow researchers to identify tiny differences in DNA across a large number of people. This allows us to find common genetic patterns in patients suffering from autoimmune diseases.


Up until recently we didn't have the tools for this, but we're able to analyze DNA on a massive scale, and it has transformed everything, explained Lee. We knew only about half dozen variations of DNA that can trigger inflammatory bowel diseases when I began my research. Today, we have over 250.


Lee and Vinuesa have been doing such research since the beginning. Their research aims to unravel the many types of diseases which doctors are currently studying and to discover the genetic mechanisms that lead to these diseases. Vinuesa explained that autoimmune diseases like Lupus for instance are present in many forms, and could have different genetic causes. If you're trying find the best treatment, this can be a problem.


There are a variety of treatments being developed however, we aren't sure which patients we should give them. We don't know what version of the disease the patient suffers from. This is an important goal of the field of autoimmune research. To find the best treatment, it's essential to know how to group Click here and categorize patients.


Lee stated that the growing incidence of autoimmune diseases around the globe meant that innovative therapies and medications were urgently required. Lee said that currently there is no cure for autoimmune diseases. They are most often seen in young adults trying to complete their education and get an employment.


This means that increasing numbers of people will need undergo surgery or receive regular injections. It's a very stressful experience for patients as well as stressing the health care system. We need new and effective treatment methods.


Rheumatoid arthritis is an Check out auto-immune disease, meaning it's due to the immune system attacking healthy body tissues. It's an unanswered question.


Your immune system naturally produces antibodies to combat viruses and bacteria.


Rheumatoid arthritis is a disease in which your immune system sends antibodies to your joints. They attack the joint tissue around the joint.


The thin layer (synovium) that covers your joints, could become inflamed and inflamed, releasing chemicals to cause harm.


bones

Cartilage is the connective tissue that connects bones and is made up of cartilage.

Tendons - The muscle tissue that connects bone and muscle

ligaments - the tissue that connects bone and cartilage

These chemicals can cause rheumatoid joint injury if the condition isn't addressed. The final result may be irreparable.


There are many theories about how the immune system can attack the joints have been suggested for example, an infection as a trigger, but none of them have been proved.

Possible risk factors

You could be at a higher risk of developing rheumatoidarthritis in the event that you fail to follow the steps listed below:


the genes you carry - there's evidence to suggest that arthritis may run in families, although the chance of inheritance is believed to be minimal as genes are only thought to play a minor role in the condition

The condition is more prevalent among women than in men. This may be due to estrogenic effects, but this isn't confirmed.

Smoking - Some evidence suggests that smokers are at greater risk for developing rheumatoid arthritis.